Klotho is a kidney-produced protein with powerful anti-aging effects that regulate phosphate and calcium balance, protect against oxidative stress, and influence key metabolic pathways. Its levels decline with age and kidney dysfunction, contributing to age-related diseases such as cardiovascular disease, chronic kidney disease, and metabolic disorders. Maintaining or restoring Klotho levels may help promote healthy aging by reducing risks of vascular calcification, organ atrophy, and metabolic imbalances, highlighting its potential as a target for preventive health strategies.
