October 5, 2025 1:38 pm PT by Jose Rossello, MD, PhD, MHCM - 0 comments

This large European study established age- and sex-specific reference values for handgrip strength in adults aged 50 and older across 27 countries, highlighting peak strength in the early 50s followed by decline with age. These values serve as practical benchmarks for identifying muscle weakness, a key predictor of frailty and health risks, enabling earlier preventive Read more…

October 5, 2025 11:58 am PT by Jose Rossello, MD, PhD, MHCM - 0 comments

Early removal of the thymus gland in early life leads to a premature aging of T cells, causing inflammation in visceral fat tissue and impairing glucose metabolism, which can contribute to glucose intolerance and increased frailty later in life. This immune-driven inflammation occurs independently of body weight and is linked to a shift toward memory Read more…

October 5, 2025 11:58 am PT by Jose Rossello, MD, PhD, MHCM - 0 comments

Klotho is a kidney-produced protein with powerful anti-aging effects that regulate phosphate and calcium balance, protect against oxidative stress, and influence key metabolic pathways. Its levels decline with age and kidney dysfunction, contributing to age-related diseases such as cardiovascular disease, chronic kidney disease, and metabolic disorders. Maintaining or restoring Klotho levels may help promote healthy Read more…