This large European study established age- and sex-specific reference values for handgrip strength in adults aged 50 and older across 27 countries, highlighting peak strength in the early 50s followed by decline with age. These values serve as practical benchmarks for identifying muscle weakness, a key predictor of frailty and health risks, enabling earlier preventive interventions to maintain physical function and independence in later life. Regular handgrip strength measurement can thus be a simple, accessible tool for monitoring healthy aging and guiding lifestyle or clinical strategies to reduce mobility limitations.
