A novel selenium supplement using redox-responsive nanoparticles (SeMSNs) has been shown to extend lifespan and delay aging-related decline in multiple organs in aged mice by maintaining calcium balance and regulating the Sik1 pathway. This approach effectively reduces oxidative stress and cellular senescence, improving muscle, kidney, and cognitive functions. These findings highlight selenium’s potential role in preventive health by targeting fundamental aging mechanisms, suggesting that advanced selenium formulations could support healthy aging beyond traditional supplementation.
